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(Chest. 1961;39:38-41.)
© 1961 American College of Chest Physicians

Combined Therapy of Inoperable Lung Carcinoma with 5-Fluorouracil and Irradiation

FORREST M. WILLET M.D., F.C.C.P.1; LAURANCE V. FOYE JR. M.D.1; MERALL ROTH M.D.1; and BYRON B. HALL M.D.1

1 The Veterans Administration Hospital.

Sixteen patients with inoperable epidermoid carcinoma of the lung were treated with local orthovoltage x-ray to a tumor dose of 2000 roentgens while receiving 5-fluorouracil. The course of combined therapy required two weeks for completion.

Toxicity occurred in 11 of 16 patients and included leucopenia, thrombocytopenia, esophagitis and pharyngitis.

Marked and rapid regression of the treated tumor mass was observed in every patient.

The simultaneous administration of low dosage x-ray and 5-fluorouracil appears to be highly effective in the treatment of epidermoid carcinoma of the lung. Further study of this, and other similar therapeutic combinations, may materially improve the otherwise dismal prognosis of patients with this disease.






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Copyright © 1961 by the American College of Chest Physicians.