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(Chest. 1961;39:162-164.)
© 1961 American College of Chest Physicians

Effect of Increasing Dosage of Streptomycin Sulfate on Serum Levels of Antimicrobially Active Drug

DAVID LEVY M.D.1; WILLIAM F. RUSSELL JR. M.D.1; SIMON NINIO M.D.1; and GARDNER MIDDLEBROOK M.D.1

1 National Jewish Hospital at Denver and the University of Colorado School of Medicine.

The effect of doubling the loading dose of streptomycin sulfate from 10 milligrams to 20 milligrams per kilogram body weight on the antimicrobially active drug was studied in six adult tuberculous patients. It was shown that by increasing the administered amount of streptomycin sulfate, an increase of the serum level of antimicrobially active drug was achieved.






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Copyright © 1961 by the American College of Chest Physicians.