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(Chest. 1961;39:678-681.)
© 1961 American College of Chest Physicians

Critical Evaluation of a Recent Trial of Isoniazid Prophylaxis

G. W. COMSTOCK M.D.1; S. H. FEREBEE 1; and F. W. MOUNT M.D.1

1 The Tuberculosis Program, Communicable Disease Center, Public Health Service, U. S. Department of Health, Education and Welfare, Washington, D. C.

Although some very interesting questions might have been raised—and answered—by this study, further analysis or speculation is not warranted. The reported findings show major discrepancies, important information is omitted, and the design of the study gives no assurance that the untreated group can in any sense be considered a control for the treated group. Because of these deficiencies, the conclusions in this paper regarding theeffect of isoniazid chemoprophylaxis on tuberculin sensitivity can not be accepted.






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Copyright © 1961 by the American College of Chest Physicians.