Experimental Intrabronchial Administration of Neomycin in Man and Animals

¹ Department of Clinical Microbiology, The Hebrew University—Hadassah Medical School., Central Tuberculosis Laboratory, University of Brazil, Rio de Janeiro, Brazil.

Neomycin was administered to 36 patients, 220 guinea pigs and 28 rabbits either intrabronchially or parenterally and the pulmonary neomycin concentration was determined bacteriologically. Those who received the intrabronchial administration showed a pulmonary neomycin concentration after three hours 700 times higher than those which received parenteral injection. Concentration of 1360 mcg./ml. in the pulmonary tissue were found four hours after intrabronchial application. After 24 hours, the level was 40 mcg./ml. Therefore, intrabronchial administration of neomycin is advisable in neomycin-sensitive pulmonary infections.