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(Chest. 1961;40:203-209.)
© 1961 American College of Chest Physicians

The Use of Chlorothiazide or Hydrochlorothiazide with Reserpine in the Office Treatment of Hypertension

DAVID B. FISHBACK M.D., F.C.C.P. and LOUIS H. CASTOR M.D.

1. Sixty patients with mild to moderate benign essential hypertension were selected from a private office practice of medicine and placed on a regimen of antitensive therapy including reserpine and a benzothiadiazine for two to 30 months.

2. This combined therapy produced significant blood pressure reduction in all but four (6.7 per cent) patients.

3. In seven more patients, the drug was withdrawn because of side effects. This figure could be greatly reduced with experience in use of the drug and patient cooperation.

4. A total of 20 experienced side effects. Most were mild and easily controlled. In none was there severe or permanent toxic effect.

5. It was concluded that this regimen was successful and practical for prolonged administration in mild to moderately severe benign essential hypertension.






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