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(Chest. 1961;40:448-453.)
© 1961 American College of Chest Physicians

A Double-Blind Study of Reserpine in Angina Pectoris

BENJAMIN A. ROSENBERG M.D., F.C.C.P.1 and MONTE MALACH M.D., F.C.C.P.1

1 Clinical Assistant Professor of Medicine, State University of New York, Downstate Medical Center.

1. A double-blind study of reserpine (0.4 mg. per day) and placebo for angina pectoris in 18 city hospital out-patients is presented. Thirteen patients received both drugs in sequence.

2. The two groups of patients were similar in clinical and laboratory findings.

3. No significant difference in improvement of exercise tolerance, nitroglycerine requirement or both was observed between the two groups.

4. The failure of reserpine to be beneficial in angina pectoris in our series may be attributed to the low incidence of hypertension, the long duration of therapy, and the apparent inefficacy of this agent.

5. The difference in side effects was negligible, except for dizziness which was significantly more frequent in the reserpine group.






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Copyright © 1961 by the American College of Chest Physicians.