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(Chest. 1962;42:359-363.)
© 1962 American College of Chest Physicians

Guanethidine

Albert N. Brest M.D.1; Paul Novack M.D.1; Hratch Kasparian M.D.1; and John H. Moyer M.D., F.C.C.P.1

1 Hypertension-Renal Unit, Hahnemann Medical College and Hospital

Guanethidine possesses a hypotensive potency similar to that of the ganglion blocking compounds. The blood pressure response obtained is most marked with the patient in the erect position; however, in contrast with the ganglioplegic drugs, guanethidine produces an antihypertensive response without the associated side effects due to parasympathetic blockade. The antihypertensive effectiveness of the compound is significantly enhanced by the concomitant administration of thiazide derivatives. Guanethidine is particularly indicated in those patients with severe diastolic blood pressure elevation.






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