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(Chest. 1963;43:50-56.)
© 1963 American College of Chest Physicians

Perfusion of the Wedged Pulmonary Artery Catheter as a Method of Assessing Pulmonary Vasomotion

William H. Bain M.D., F.C.C.P.1; Joseph R. Lancaster M.D.1; Richard H. Evans M.D.1; F. G. Schoenfeld B.S.1; Peter V. Moulder M.D., F.C.C.P.1; and William E. Adams M.D., F.C.C.P.1

1 Department of Surgery, University of Chicago

The perfused wedged catheter technique was used (a) with the catheter passed in the conventional manner and (b) with the catheter introduced directly into a pulmonary artery and wedged, through a thoracotomy.

An important source of artifact in the transcandiac wedged catheter is demonstrated to be cardiac effect on the catheter resistance.

Using the directly wedged catheter, through the open chest, nitrogen-breathing hypoxia caused vasodilation in the wedge segment. Serotonin, epinephrine, nor-epinephnine, acetylcholine and hypercapnia caused vasoconstriction. The constrictor effect of epinephrine and nor-epinephrine was blocked or reversed by tolazoline, but not the effect of serotonin or hypercapnia.

The perfused wedged catheter is a valuable tool for the experimental evaluation of pulmonary vasomotion.






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Copyright © 1963 by the American College of Chest Physicians.