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(Chest. 1963;43:605-612.)
© 1963 American College of Chest Physicians

Specific Epithelial Degeneration (Ciliocytophthoria) in Inflammatory and Malignant Respiratory Disease

Milton B. Rosenblatt M.D., F.C.C.P.1; Salvador Trinidad M.D.2; James R. Lisa M.D.3; and Victor Tchertkoff M.D.4

1 Associate Clinical Professor, New York Medical College and Visiting Physician, Metropolitan Hospital
2 Pathologist, Doctors Hospital
3 Director, Pathology Service, Department of Hospitals, New York City
4 Assistant Professor, New York Medical College and Pathologist-in-charge, Metropolitan Hospital

1. Ciliocytophthoria is a specific form of degeneration of columnar ciliated epithelium of the respiratory tract.

2. Using the Papanicolaou staining technique for the examination of sputum, CCP cells are easily recognized by the formation of tufts, pyknotic and clumped nuclei, and by the presence of acidophilic inclusion bodies in the cytoplasm and nucleus.

3. A study of 301 cases with varied respiratory diseases showed the highest incidence of CCP to occur in patients with acute viral infections and bronchogenic carcinoma.

4. Among 77 cases positive for CCP, 65 (84 per cent) occurred in patients with either viral or malignant respiratory disease.

5. The relationship of CCP formation to viral disease and malignancy is explained by an epitheliotropic process occurring in both conditions resulting in the desquamation, and subsequent degeneration, of large numbers of columnar ciliated epithelial cells.






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Copyright © 1963 by the American College of Chest Physicians.