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(Chest. 1963;44:505-508.)
© 1963 American College of Chest Physicians

Intrapleural Insufflation of Dicetyl Phosphate to Promote Pleural Symphysis

Eugene G. Laforet M.D.1 and A. C. Hering 2

1 Clinical Instructor in Thoracic Surgery, Boston University School of Medicine, Cdr. MC, USNR
2 Chief of Thoracic Surgery, U. S. Naval Hospital, Chelsea

In six dogs, dicetyl (di-n-hexadecyl) phosphate was insufflated into one pleural cavity, with the contralateral space serving as a control. Broad viscero-parietal adhesions developed on the treated side. Histologically there was no distinct evidence of damage to the underlying lung. In clinical practice, the production of pleural symphysis has been of advantage in the treatment of spontaneous pneumothorax and of intractable malignant pleural effusion. Dicetyl phosphate and related compounds are deserving of further evaluation in the search for an agent that may be clinically satisfactory in these situations.






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