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(Chest. 1964;46:82-86.)
© 1964 American College of Chest Physicians

Propylene Glycol Aerosolization and the Diagnosis of Pulmonary Histoplasmosis

Manohar D. Singh M.D.1 and Robert G. Garrison PH.D.2

1 Kansas city, Missouri
2 Research Laboratory, Veterans Administration Hospital, and the Department of Medical Microbiology, Kansas University Medical Center

It has been established that propylene glycol aerosolization to induce sputum from patients with unproductive cough has diagnostic value in cytologic examinations and for culture of acid-fast bacilli. In contrast, propylene glycol in concentrations found in sputum induced by aerosolization appears to interfere with yeast-to-mycelial phase dimorphism of Histoplasma capsulatum. Usual diagnostic cultural procedures rely upon conversion of the tissue phase (yeast phase) to the saprophytic phase (mycelial phase). It would appear, therefore, that induction of sputum for cultural procedures in the diagnosis of pulmonary histoplasmosis by the use of propylene glycol aerosol may significantly handicap laboratory confirmation.






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