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(Chest. 1965;48:178-186.)
© 1965 American College of Chest Physicians

The Clinical Pharmacology of Postganglionic Sympathetic Blocking Agents

William B. Abrams M.D., F.C.C.P.1; Robert Pocelinko M.D.1; Robert A. Moe Ph.D.1; Harold Bates Ph.D.1; Lonnie Hanauer M.D.1; and Silvestre Camacho M.D.1

1 Special Treatment Units of the Newark City and Beth Israel Hospitals and the Departments of Pharmacology and Clinical Pharmacology of Hoffmann-La Roche Inc.

We have seen that a variety of pharmacologic agents can lower blood pressure by more or less unique biochemical mechanisms which inhibit the transmission of tonic stimuli through the sympathetic postganglionic neuroeffector junction. We have presented evidence that these mechanisms, chiefly derived in the laboratory, also obtain in people. The hemodynamic effects of these drugs, however, cannot at present be correlated with their biochemical mechanisms. Furthermore, the clinical significance of these mechanisms seems more related to side effects than to the desired effect on blood presure.






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Copyright © 1965 by the American College of Chest Physicians.