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(Chest. 1965;48:347-350.)
© 1965 American College of Chest Physicians

Effect of Blood Gases and Acid-Base Disturbances on the Pulmonary Circulation

Daniel H. Simmons M.D., F.C.C.P.1; Leonard M. Linde M.D.1; and Bertrand J. Shapiro M.D.1

1 Division of Medicine, Cedars-Sinai Medical Center, Mount Sinai Division, and the Departments of Medicine, Physiology and Pediatrics, University of California Medical Center

1. Factors affecting pulmonary hemodynamics (cardiac output and pulmonary vascular resistance) are outlined. Among these are changes in blood gases (pO2, pCO2 and pH).

2. Major effects on both flow and resistance are due to decreased pO2, increased pCO2 and decreased pH in contrast to changes in opposite directions.

3. These blood gas changes, which are those usually observed in pulmonary disease all lead to increased pulmonary vascular resistance, direct myocardium depression, and myocardium stimulation via increased sympatho-adrenal discharge.

4. These blood gas changes in normal individuals lead to increased cardiac output in spite of direct myocardial depression and increased pulmonary resistance. In pulmonary disease with cor pulmonale, inappropriately low cardiac output is usually observed because of increased work of the heart and myocardial depression.






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Copyright © 1965 by the American College of Chest Physicians.