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(Chest. 1965;48:401-407.)
© 1965 American College of Chest Physicians

The Amplitude of the First Heart Sound In Experimentally Induced Atrial Fibrillation

Tsuguya Sakamoto M.D.1; Reizo Kusukawa M.D.2; Donald M. MacCanon PH.D.3; and Aldo A. Luisada M.D., F.C.C.P.4

1 Chief, Laboratory of Phonocardiography. University of Tokyo, The Second Department of Internal Medicine, Faculty of Medicine, Tokyo, Japan)
2 Chief director, Department of Cardiac Laboratory, The Clinical Central Laboratory, Kyoto University Hospital (Kyoto, Japan)
3 Associate Professor and Associate Director, Division of Cardiovascular Research; Associate Professor of Physiology, The Chicago Medical School; Career program awardee, National Heart Institute, United States Public Health Service
4 Director, Division of Cardiovascular Research, The Chicago Medical School

The hemodynamic determinants of the amplitude of the first heart sound during experimentally induced atrial fibrillation were studied in eight anesthetized dogs. First sound amplitude and preceding diastolic interval tended to have a parabolic relationship. Exceptions observed during short runs of tachycardia were related to the adequacy of the previous beats. As in sinus rhythm, the amplitude of the first heart sound is linearly related to the rate of left ventricular pressure rise.

These observations adequately explain the divergent views of previous investigators regarding the variations in the amplitude of the first heart sound in atrial fibrillation.






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Copyright © 1965 by the American College of Chest Physicians.