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(Chest. 1966;50:161-172.)
© 1966 American College of Chest Physicians

Coronary Sinus Blood Flow During Oxygen Ventilation at 1 ATA and 3 ATA

N. G. Meijne M.D.1; J. P. Straub 1; A. B. Bulterijs 1; and C. de Boer 1

1 Surgical Department of the University of Amsterdam at the Wilhelmina Gasthuis

The coronary sinus blood flow was measured in eight dogs during ventilation with air and oxygen at 1 ATA and 3 ATA. It appears that the decrease of coronary flow which occurs already at 1 ATA by changing air ventilation to oxygen ventilation continues during compression to 3 ATA in a hyperbaric chamber. The lactic acid level of the coronary sinus blood decreases but the lactic acid extraction by the myocardium stays at the same level as well as the oxygen extraction; apparently at 1 ATA and at 3 ATA the aerobic metabolism of normal hearts is the same.

From the decrease of flow during oxygen ventilation, it is supposed to be advisable to administer coronary vasodilators in patients treated with oxygen under increased atmospheric pressure who are expected to have a significant amount of sclerosis of the coronary arteries.






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