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(Chest. 1966;50:595-600.)
© 1966 American College of Chest Physicians

Comparative Evaluation of Blood Levels and Tolerance of Sodium PAS nd Conjugated PAS and Ascorbic Acid

James M. Schless M.D., F.C.C.P.1; Robert M. Inglis M.D.1; James H. Hammond M.D., F.C.C.P.1; and John M. Hale Ph.D.1

1 San Antonio State Tuberculosis Hospital and the Texas State Department of Health

Blood levels obtained with PAS-C given in single daily dosage of 6 gm. and a divided dose of 12 gm. were compared with those obtained with sodium PAS in a single daily dose of 7.5 gm. and divided doses of 15 gm. PAS-C tends to peak slower, and can be detected for a longer period than doses of sodium PAS comparable in acid content. Individual peak levels tend to be significantly higher with PAS-C than with sodium PAS in the regimens tested. A measurable residual level is noted when PAS-C is given in 12 gm. doses. The implication of the differences in blood level curves obtained with PAS-C and sodium PAS are discussed, and the need for a comparative study of combined treatment regimens utilizing a 6 gm. single dose of PAS-C versus an equivalent single dose of sodium PAS is pointed out.






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Copyright © 1966 by the American College of Chest Physicians.