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(Chest. 1967;51:172-176.)
© 1967 American College of Chest Physicians

Procainamide Induced Lupus Erythematosus Syndrome

Howard S. Sanford M.D.1; Allan K. Michaelson M.D.1; and Morton M. Halpern M.D., F.C.C.P.1

1 School of Medicine, University of Miami, the Jackson Memorial Hospital and the Cedars of Lebanon Hospital

Two patients, ages 69 and 74, who developed lupus erythematosus syndrome associated with procainamide therapy have been described. Symptoms developed two months and 11 months respectively after initiation of therapy. The symptoms gradually subsided upon discontinuation of the drug together with corticosteroid therapy. Review of 12 other reported cases indicates that arthralgias and pleural pain are early and prominent symptoms, and should alert the physician to this unusual drug reaction.






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Copyright © 1967 by the American College of Chest Physicians.