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(Chest. 1967;51:248-255.)
© 1967 American College of Chest Physicians

Effects of Diphenylhydantoin (Dilantin) on Peripheral and Coronary Circulation and Myocardial Contractility in the Experimental Animal

D. N. Gupta M.D.1; M. O. Unal M.D.1; F. A. Bashour M.D., F.C.C.P.2; and W. R. Webb M.D., F.C.C.P.3

1 Departments of Surgery and Medicine, The University of Texas Southwestern Medical School
2 Associate Professor of Medicine
3 Professor of Surgery

The effects of diphenylhydantoin have been investigated in mongrel dogs with intact circulation and in situ heart-lung preparations in the open-chest dog.

Diphenylhydantoin in increasing dosage resulted in a slight decrease in the cardiac output, systemic arterial pressure and heart rate. A transient negative inotropic effect lasting up to five minutes was observed. Coronary blood flow showed a marked increase which was ascribed to a direct vasodilating effect on the coronary vessels. Myocardial oxygen consumption remained unchanged during a constant workload.






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Copyright © 1967 by the American College of Chest Physicians.