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(Chest. 1967;51:282-287.)
© 1967 American College of Chest Physicians

Ethacrynic Acid: A Non-Diabetogenic Diuretic

Edwin Feldman M.D., F.C.C.P.1 and Seymour Diamond M.D.2

1 Chicago, Illinois
2 Illinois Masonic Hospital

A new and potent diuretic agent, ethacrynic acid, has been investigated in a preliminary study, to determine the effect on glucose tolerance in non-diabetics, mild diabetics and severe diabetics. The study indicates that ethacrynic acid has no significant diabetogenic effect. Side effects attributable to ethacrynic acid occurred in five patients. The marked potency of the drug as a diuretic and its lack of diabetogenic effect in contradistinction to thiazides and phthalimidines make it, with proper caution concerning potential side effects, a valuable new agent for use in cases of refractory edema.






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Copyright © 1967 by the American College of Chest Physicians.