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(Chest. 1967;51:304-305.)
© 1967 American College of Chest Physicians

In Vitro Study of Alkylating Agents Against Tubercle Bacilli

Yves Jerome M.D.1

1 Philadelphia, Pennsyvania

The present study showed the in vitro bacteriostatic or bactericidal effect of thiotepa and the mechlorethamine hydrochloride (Mustargen).

The effective concentration is 10 µg. per cent with thio-tepa and 20 µg. per cent with mechlorethamine hydrochloride.

Lower concentrations of those drugs were found less effective.

The contact of alkylating agents with tubercle bacilli was maintained for ten minutes.






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Copyright © 1967 by the American College of Chest Physicians.