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(Chest. 1967;52:46-49.)
© 1967 American College of Chest Physicians

The Effect of Influenza Vaccine Administration on Tuberculin Skin Sensitivity

Burton Zweiman M.D.1; Joseph E. Pappano Jr. M.D.1; and Eugene A. Hildreth M.D.1

1 Allergy and Immunology Section, Department of Medicine, Hospital and School of Medicine, University of Pennsylvania

1. The effect of influenza vaccine immunization on pre-existent tuberculin reactivity was carried out in 21 subjects. Nine of these reacted strongly to intermediate strength purified protein derivative; the other 12 were positive only to second strength purified protein derivative.

2. There was modest depression of the skin reaction in some individuals. However, in only two subjects, both with less pronounced baseline reactivity, did the tuberculin skin test become transiently negative. There was no correlation between alteration of skin reactivity and antibody response.

3. It was concluded that under the circumstances of these studies, influenza vaccine administration did not generally alter the diagnostic significance of tuberculin skin testing.






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