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(Chest. 1967;52:342-349.)
© 1967 American College of Chest Physicians

Chronic Expiratory Air-Flow Obstruction — Cause or Effect of Centrilobular Emphysema?

Philip C. Pratt M.D., F.C.C.P.1 and George A. Klugh B.A.2

1 Duke University Medical Center, Durham, North Carolina
2 Departments of Pathology, Ohio Tuberculosis Hospital and the Ohio State University College of Medicine

1. This report presents the results of postmortem function and structure measurements and their correlations in 139 normal lungs and 101 lungs with centrilobular emphysema (CLE).

2. Total lung volume is consistently increased above normal in lungs with CLE even when the disease is discovered incidentally in persons dying of other diseases, including trauma. The greater the extent of emphysema, the larger the total lung volume.

3. The one-second expiratory volume is slightly lower than normal in lungs with slight emphysema and is markedly reduced in lungs with moderate or severe disease, i.e. more than 30 per cent.

4. These data are interpreted as supporting the conclusion that emphysema causes expiratory air-flow obstruction rather than air-flow obstruction being the cause of emphysema.






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Copyright © 1967 by the American College of Chest Physicians.