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(Chest. 1967;52:481-484.)
© 1967 American College of Chest Physicians

Cardiac Metastasis in Lymphoma and Leukemia

Benita V. Javier M.D.1; William J. Yount M.D.2; David J. Crosby M.D., F.C.C.P.3; and Thomas C. Hall M.D.4

1 Medical Resident, Pondville Hospital, Walpole
2 Medical Service, USPHS Hospital, Boston
3 Chief, Medical Service, USPHS Hospital, Boston, and Associate Clinical Professor of Medicine, Boston University School of Medicine
4 Chief of Pharmacology, Children's Cancer Research Foundation, Harvard Medical School

Cardiac metastases were present in 53 of 247 necropsied patients with leukemias and lymphomas. The incidence was highest in reticulum cell sarcoma and leukemia and lowest in Hodgkin's disease. Clinical findings suggesting cardiac metastases were more common in lymphoma patients, and leukemic metastases were frequently clinically silent. Electrocardiographic changes were usually non-specific except in patients with pericarditis and in one patient with myocardial infarction due to coronary occlusion by a nodule of metastatic Hodgkin's disease. Careful screening of patients with responsive tumors where the incidence of cardiac spread is known to be high, yields occasional cases where local therapy is justified and of benefit.






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Copyright © 1967 by the American College of Chest Physicians.