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(Chest. 1967;52:602-605.)
© 1967 American College of Chest Physicians

Effects of Alcohol on Myocardial Contractility

W. R. Webb M.D., F.C.C.P.1; D. N. Gupta M.D.1; W. A. Cook M.D., F.C.C.P.1; W. L. Sugg M.D.1; F. A. Bashour M.D., F.C.C.P.1; and M. O. Unal M.D.1

1 Departments of Surgery and Medicine, University of Texas Southwestern Medical School

1. Ethyl alcohol in concentrations up to 900 mg per cent was not found to have any appreciable effect on myocardial contractility in the isolated heart-lung preparation in the open chest dog. This preparation tends to evaluate primary effects of a drug on the heart and minimize secondary effects.

2. These findings are in contrast to the myocardial depression caused by alcohol in the intact animal that is unprotected from the secondary effects of alcohol.






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Copyright © 1967 by the American College of Chest Physicians.