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1 Durham, North Carolina
The results of surgery in 60 patients with isolated ventricular septal defect and pulmonary hypertension is reported. The use of pulmonary to systemic flow and resistance ratios appears to be an important prognostic method in determining the operability of patients with a ventricular septal defect and severe pulmonary hypertension. A pulmonary to systemic resistance ratio (Rp/Rs) of .4 or less suggests mild pulmonary vascular disease, and that the pulmonary hypertension is secondary to a high flow shunt. A Rp/Rs ratio of 0.5 or greater implies severe pulmonary vascular obstruction and that surgery is contraindicated.
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