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(Chest. 1968;53:263-270.)
© 1968 American College of Chest Physicians

Treatment of Digitalis Toxicity by Diphenylhydantoin (Dilantin)

F. A. Bashour M.D., F.C.C.P.1; R. E. Edmonson M.D.1; D. N. Gupta M.B.1; and Ronald Prati M.D.1

1 Department of Medicine, The University of Texas Southwestern Medical School

Diphenylhydantoin was administered to 11 patients with digitalis intoxication. In the twelfth patient, PAT with block appeared during diphenylhydantoin prophylactic measure. The drug was used intravenously in ten patients.

Diphenylhydantoin is rapidly and highly effective in abolishing ventricular arrhythmias (tachycardia, bigeminy, and multifocal premature ventricular beats), but it is less effective in abolishing atrial arrhythmias. Diphenylhydantoin is a safe antiarrhythmic drug when properly used.






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Copyright © 1968 by the American College of Chest Physicians.