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(Chest. 1968;53:541-544.)
© 1968 American College of Chest Physicians

Effect of Pulmonary Pathogens on Surfactant

Myron Rose M.S.1 and Donald A. B. Lindberg M.D.2

1 University of Missouri School of Medicine
2 Associate Professor of Pathology, and Director, Medical Center Computer Program

A crude preparation of pulmonary surfactant was obtained from rabbit lungs by lavage of the broncho-alveolar space. Lyophilized and reconstituted solutions of surfactant were incubated with various pure strains of bacteria.

Some bacteria reduced surface tension during incubation, these were P. aeruginosa, A. aerogenes, Proteus species, K. Pneumoniae, and to a lesser extent D. pneumoniae. Gram positive bacteria did not appear to alter the surface tension of the pulmonary surfactant solutions; these included S. aureus, S. epidermidis, S. pyogenes (Lancefield Group A), S. viridans, and S. fecalis.






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Copyright © 1968 by the American College of Chest Physicians.