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(Chest. 1969;55:98-100.)
© 1969 American College of Chest Physicians

Effect of Chemotherapeutic Agents on Chromosomes of Patients with Lung Cancer

David T. Kaung M.D.1 and Arlis A. Swartzendruber 1

1 Veterans Administration Hospital, Iowa City

Chromosome studies were made on peripheral blood leukocytes from 20 patients with lung cancer before and during chemotherapy. The chemotherapies consisted of clophosphamide (Cytoxan), methotrexate, hydroxyurea, and a triple drug regimen of Cytoxan, methotrexate and streptonigrin. Peripheral blood studies of the chromosomes revealed a slightly increased incidence of major (fragments, dicentrics, translocations) and minor chromosome aberrations (breaks) during chemotherapy.






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Copyright © 1969 by the American College of Chest Physicians.