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(Chest. 1969;55:295-300.)
© 1969 American College of Chest Physicians

Clinical and Experimental Observation of Serum Enzyme Changes Occurring after Surgical Myocardial Revascularization

Cesar A. Vera M.D.1; Teruo Hirose M.D., F.C.C.P.2; and Charles P. Bailey M.D., F.C.C.P.3

1 Assistant Director, Cardiovascular Laboratory, St. Barnabas Hospital, Bronx, New York
2 Director, Cardiovascular Laboratory, St. Barnadas Hospital, Bronx, New York
3 Director, Department of Thoracic and Cardiovascular Surgery, St. Barnadas Hospital, Bronx, New York

The activity of SGOT and LDH was studied in a selected group of patients and in experimental animals undergoing anterior and posterior myocardial revascularization. In both series, enzymatic elevation patterns similar to those seen in acute myocardial infarction were observed. The SGOT level reached its peak on the first postoperative day and returned to normal by the sixth or seventh day. The LDH level reached its peak 48 hours after surgery, followed by a gradual fall to normal between the tenth and 14th day. Having eliminated the influence of massive surgical stress or extracorporeal circulation, it was concluded that direct trauma to the wall of the left ventricle during construction of a myocardial tunnel is the primary factor responsible for a rise of serum enzyme activity as observed in the following revascularization procedures.







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Copyright © 1969 by the American College of Chest Physicians.