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(Chest. 1969;56:37-42.)
© 1969 American College of Chest Physicians

Comparative Effects of Digoxin and Proscillaridin in the Heart-Lung Preparation

Haruo Ito M.D.1; Young W. Cho M.D.2; and Domingo M. Aviado M.D.3

1 Professor of Pharmacology, Kanagawa Dental College, Yokosuka, Japan
2 Assistant Medical Director, Department of Medical Research, W. S. Merrell Company, Cincinnati, Ohio
3 Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

Proscillaridin and digoxin were compared in 15 heart-lung preparations. The ratios of therapeutic dose to lethal dose for each glycoside were approximately similar. Both glycosides increased myocardial efficiency and increased the production of ammonia by the heart muscle. Proscillaridin was more likely to increase myocardial efficiency than digoxin in the heart that has been depressed by sodium pentobarbital. The significance of these observations in the heart in failure due to organic disease remains to be elucidated.






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Copyright © 1969 by the American College of Chest Physicians.