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(Chest. 1969;56:114-117.)
© 1969 American College of Chest Physicians

Lymphedema, Pleural Effusions and Yellow Nails

Associated Immunologic Deficiency

Stanley S. Siegelman M.D.1; Bruce H. Heckman M.D.1; and Jack Hasson M.D.1

1 Montefiore Hospital and Medical Center, Bronx, New York

Two siblings with congenital lymphedema had recurrent pleural effusions in adult life. The brother also had yellow toenails and thus represents an example of the syndrome of lymphedema, pleural effusions, and yellow nails. An immunologic deficiency state in these patients was suggested by recurrent bronchopulmonary and skin infections, hypogammaglobulinemia, and episodes of lymphopenia. The sister developed Hodgkin's disease terminally, an interesting occurrence in keeping with the increased incidence of lymphatic malignancies in patients with immunologic deficiency.




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