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(Chest. 1970;57:141-147.)
© 1970 American College of Chest Physicians

Familial Cardiomyopathy

A Clinical, Hemodynamic and Angiographic Study in One Family

S. Serge Barold M.B.1; Joseph W. Linhart M.D.2; Frank J. Hildner M.D., F.C.C.P.3; Arkadi Rywlin M.D.4; and Philip Samet M.D., F.C.C.P.5

1 Staff Physician, Division of Cardiology, Department of Internal Medicine, Mount Sinai Hospital, Miami Beach, Florida
2 Director, Cardiac Catheterization Laboratory, University of Texas Medical School, San Antonio, Texas
3 Director, Clinical Catheterization Laboratory, Division of Cardiology, Department of Internal Medicine, Mount Sinai Hospital, Miami Beach, Florida
4 Head, Department of Pathology, Mount Sinai Hospital, Miami Beach, Florida
5 Chief, Division of Cardiology, Department of Internal Medicine, Mount Sinai Hospital, Miami Beach, Florida

The diagnosis of familial cardiomyopathy was established by cardiac catheterization and cineangiography in six patients belonging to the same family. Five patients exhibited obstructive cardiomyopathy of the idiopathic hypertrophic subaortic stenosis type, while one displayed myocardial hypertrophy with a dilated poorly contractile left ventricle without obstructive phenomena. These observations support the concept that idiopathic hypertrophic subaortic stenosis and idiopathic myocardial hypertrophy represent different manifestations of the same disease. The disease was transmitted as an autosomal mendelian dominant with incomplete penetrance.







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Copyright © 1970 by the American College of Chest Physicians.