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(Chest. 1970;58:558-561.)
© 1970 American College of Chest Physicians

Pharmacology of a New Antianginal Drug: Perhexiline

III. Bronchopulmonary System in the Dog and Humans

Oscar Feinsilver M.D., F.C.C.P.1; Young W. Cho M.D., F.C.C.P.1; and Domingo M. Aviado M.D.1

1 Medical Service, St. Vincent Hospital, Worcester, Massachusetts, the Department of Pharmacology, University of Pennsylvania, Philadelphia, and the Department of Medical Research, The William S. Merrell Company, Division of Richardson-Merrell, Inc., Cincinnati

Perhexiline elicited bronchodilatation in anesthetized dogs and asthmatic patients. In the latter, the effect was manifested by a fall in airway resistance. In some patients, an increase was observed in forced expiratory volume, lung volume, forced vital capacity and maximum expiratory flow rate respectively.







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