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(Chest. 1970;58:577-581.)
© 1970 American College of Chest Physicians

Pharmacology of a New Antianginal Drug: Perhexiline

I. Coronary Circulation and Myocardial Metabolism

Young W. Cho M.D., F.C.C.P.1; Michael Belej M.S.1; and Domingo M. Aviado M.D.1

1 Department of Pharmacology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, and the Department of Medical Research, William S. Merrell Company, Division of Richardson-Merrell, Inc., Cincinnati, Ohio

In the anesthetized dog with right-heart bypass the injection of perhexiline was followed by the vasodilatation of the coronary, systemic and pulmonary vascular beds. There was a fall in left ventricular work, index of energy utilization, and myocardial oxygen consumption. The ratio of Dgr cardiac output Dgr oxygen consumption was elevated following the administration of perhexiline. All these effects of perhexiline are potentially desirable in the treatment of coronary insufficiency.






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