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(Chest. 1970;58:581-585.)
© 1970 American College of Chest Physicians

Pharmacology of a New Antianginal Drug: Perhexiline

II. Heart Rate and Transmembrane Potential of Cardiac Tissue

Shigeru Matsuo D.Sc.1; Young W. Cho M.D., F.C.C.P.1; and Domingo M. Aviado M.D.1

1 Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, and the Department of Medical Research, The Wm. S. Merrell Company, Division of Richardson-Merrell, Inc., Cincinnati, Ohio

The administration of perhexiline was followed by slowing of heart rate in the anesthetized dog, the isolated rat heart and the isolated rabbit heart. This effect was not altered by previous vagotomy or the prior injection of either atropine or sotalol in the dog. A local effect on the rat atrial muscle and on the rabbit sinoatrial node was confirmed by microelectrode technique. There was prolongation of depolarization time and of repolarization time, suggesting that this drug may be useful in situations in which coronary insufficiency is complicated by increase in excitability of atrial muscle and of the sino-atrial node.






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Copyright © 1970 by the American College of Chest Physicians.