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(Chest. 1971;59:232-235.)
© 1971 American College of Chest Physicians

The Potential Hazard of Oxygen after Bilateral Cordotomy

Abraham S. Kuperman M.D.1; Rogelio B. Fernandez M.D.2; and Hubert L. Rosomoff M.D.3

1 Assistant Professor of Medicine; Chief, Cardiopulmonary Laboratory, Albert Einstein College Hospital
2 Cardiopulmonary Laboratory, Albert Einstein College Hospital
3 Charles Frost Professor and Chairman, Department of Neurological Surgery, Albert Einstein College of Medicine

The potential hazard of oxygen administration to patients who have had bilateral cervical cordotomy was demonstrated in two patients. Both patients developed sleep-induced apnea (Ondine's curse) after cordotomy. The administration of oxygen resulted in a unique cyclic breathing pattern the exact mechanism of which remains obscure. In one patient there was also marked hypoventilation while breathing oxygen. This increased dependence on the aortic-carotid reflex mechanism to regulate ventilation indicated a depression of central chemosensitivity, which could be ascribed to ablation of the reticular system pathways in the spinal cord with deafferentation of the reticular formation. These observations provide further support for the hypothesis that there are afferent fibers concerned with respiratory control in the ventral quadrant of the cervical spinal cord.






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Copyright © 1971 by the American College of Chest Physicians.