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(Chest. 1971;59:284-288.)
© 1971 American College of Chest Physicians

Effectiveness of Venous Oxygenation during Progressive Hypoxia

Monte Lichtiger M.D.1; Joanne McDermott B.S.2; and Frank Gollan M.D.3

1 Departments of Anesthesiology and Surgery, University of Miami School of Medicine, and the Veterans Administration Hospital, Miami, Florida
2 Research Associate, Veterans Administration Hospital
3 Chief, Nuclear Medicine Service, Veterans Administration Hospital; Research Professor of Anesthesiology and Surgery, University of Miami School of Medicine, Miami, Florida

This study was undertaken to assess the effect of extracorporeal oxygenation on the heart and on gas exchange. In acute experiments on anesthetized, closed-chest greyhounds, venovenous shunting under pulsatile pressure did not affect heart rate, cardiac output or arterial blood pressure. Then progressive hypoxia was produced by hypoventilation and the venous oxygen tension was raised by mechanical oxygenation. The magnitude of this effect was inversely related to the degree of existing hypoxia. With the blood flow from a single cannula in a femoral vein and with an efficient oxygenator, a volume of oxygen amounting to half of the animal's consumption could be transferred.






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Copyright © 1971 by the American College of Chest Physicians.