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1 Division of Respiratory Diseases, Department of Medicine
2 Department of Surgery (University of Basle/Switzerland)
Obstructions of the central airways (thoracic trachea and main bronchi) can be divided in two main categories, namely: 1) fixed stenoses independent of the thoracic pressure, and 2) non-fixed stenoses dependent on the thoracic pressure. Methods of diagnosing central airway obstructions are the forced expiration curve, bronchoscopy, the tracheal diameter/transmural pressure diagram and, most important, the measurement of intrabronchial pressure in the different segments of the intrathoracic airways. Preliminary experiments in dogs showed that the patterns of the expiratory alveolo-glottic pressure drop changed considerably when the normally taut dorsal membrane of trachea was replaced by a loose skin-flap indicating exactly the site of the artificial weakness of the airways. In four patients with non-fixed, pressure dependent obstructions of the central airways, patterns of expiratory transbronchial pressure-drop were plotted and the share of peripheral and central bronchi in total expiratory flow resistance measured and compared with the findings in healthy man as well as before and after reinforcement of the relaxed dorsal tracheobronchial membrane by application of a strip from the sheath of the straight abdominal muscle. Effects on clinical features such as efficiency of cough and breathlessness during exercise and on pulmonary function tests are evaluated and indications for the intervention discussed.
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