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(Chest. 1971;60:166-169.)
© 1971 American College of Chest Physicians

Chronic Bronchitis: A Seldom Noted Manifestation of Homozygous Alpha1-antitrypsin Deficiency

George A. Falk M.D.1 and James P. Smith M.D.1

1 Edward Livingston Trudeau Fellow, American Thoracic Society and Assistant Professor of Medicine

The elder of two brothers with homozygous alpha1-antitrypsin deficiency died at age 65 after many years of chronic bronchitis and recurrent pneumonia. His younger brother, a 56-year-old nonsmoker, suffers from persistent bronchitis with only minimal abnormalities of pulmonary function. The lung disease associated with homozygous alpha1-antitrypsin deficiency may thus take the form of chronic bronchitis and not only dry, panacinar emphysema as is often assumed.




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A. Cuvelier, J.-F. Muir, M.-F. Hellot, D. Benhamou, J.-P. Martin, J. Benichou, and R. Sesboue
Distribution of {alpha}1-Antitrypsin Alleles in Patients With Bronchiectasis
Chest, February 1, 2000; 117(2): 415 - 419.
[Abstract] [Full Text] [PDF]


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Copyright © 1971 by the American College of Chest Physicians.