Effects of Cigarette Smoking on Hemodynamics at Rest and During Exercise. I. Normal Subjects

¹ Department of Medicine, Section of Cardiology, Pritzker School of Medicine, University of Chicago

Cardiovascular responses to submaximal graded upright exercise were investigated by pulmonary and subclavian arterial catheterization in nine healthy young men before and after smoking a single cigarette. At rest, after smoking, the mean cardiac index (CI) and mean heart rate (HR) increased, while arteriovenous oxygen difference (AVDO₂), stroke index (SI) and mean PA pressure remained unchanged. During successively increasing levels of exercise, the HR was greater and the SI lower than values for comparable work before smoking; the AVCO₂, VO₂, PA presure, systemic vascular resistance, lactate production, V_E and arterial PO₂ did not change significantly. By decreasing the stroke volume response to exercise, smoking a single cigarette significantly alters the hemodynamic response to exercise in a direction opposite to physical training.

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