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(Chest. 1972;61:86-90.)
© 1972 American College of Chest Physicians

Distinctive Ultrastructural Findings in a Case of Idiopathic Interstitial Pneumonia

Paul A. Shurin M.D.1 and A. Jay Block M.D.1

1 Departments of Pathology and Medicine, Johns Hopkins Hospital and the Johns Hopkins University School of Medicine, Baltimore

A patient with chronic interstitial pneumonia was treated with steroids with excellent results. Electron microscopic examination of a lung biopsy taken before treatment showed the functional defect to be associated with a gross increase in the width of the anatomic barrier to gaseous diffusion into the blood. A peculiar sudanophilic and osmiophilic inclusion was identified in the cytoplasm of his alveolar macrophages, and it is postulated that this material, which is of obscure origin, was the primary lung irritant.






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Copyright © 1972 by the American College of Chest Physicians.