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(Chest. 1972;61:392-394.)
© 1972 American College of Chest Physicians

Deep Entomophthora Phycomycotic Infection Reported for the First Time in the United States

Herbert L. Eckert M.D.1; George H. Khoury M.D.2; R. Scott Pore Ph.D.3; Enid F. Gilbert M.D.4; and James R. Gaskell M.D.2

1 Department of Medicine (Division of Preventive Medicine, West Virginia University School of Medicine, Morgantown
2 Department of Pediatrics, West Virginia University School of Medicine
3 Department of Microbiology, West Virginia University School of Medicine
4 Department of Pathology, West Virginia University School of Medicine

A mediastinal phycomycotic infection in a Caucasian infant caused by Entomophthora was confirmed by culture and histologic examination of biopsy material. The patient had heart failure resulting from the invasive mediastinal mass, eosinophilia, and hyperglobulinemia. Unlike other cases of Entomophthora disease, usually confined to subcutaneous areas and limited to the tropics, this present case involved a deep infection in a patient who lived in a temperate zone. The disease was amenable to amphotericin B therapy.




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