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(Chest. 1972;61:488-491.)
© 1972 American College of Chest Physicians

Use of Hydrocortisone in the Treatment of Acute Myocardial Infarction

Summary of a Clinical Trial in 446 Patients

D. Barzilai M.D.1; J. Plavnick M.D.2; A. Hazani M.D.2; R. Einath M.D.2; N. Kleinhaus M.D.2; and Y. Kanter M.D.2

1 Department of Internal Medicine C, Rambam Medical Center, ABA Khousi Medical School, Haifa, Israel
2 Department of Internal Medicine C, Rambam Medical Center, ABA Khousi Medical School, Haifa, Isral

Four hundred and forty-six patients with acute myocardial infarction were assigned to one of three departments in a hospital on the basis of the day of the week they were admitted. The members of this group were treated with hydrocortisone during the first three days of their hospitalization. For a comparison group, 491 patients assigned in a similar way to other medical departments were chosen. The aim of this study was to compare death rates only. We conclude that: (1) mortality in the treated group was 14.5 percent as compared to 23.2 percent in the comparison group; (2) patients suffering from their first infarction had a significantly better chance of survival in the treated group, compared to those with recurrent infarction, whether treated or not treated; and (3) in the first three days of treatment there is a significantly lower mortality rate in the treated group. We believe that our results suggest an important place for the use of hydrocortisone in cases of fresh myocardial infarction in hospitals.




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[Abstract] [Full Text] [PDF]


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