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(Chest. 1972;61:494-496.)
© 1972 American College of Chest Physicians

The Sinus Node in Chronic Granulocytic Leukemia

A. G. Suryaprasad M.D.1; Ellis J. Van Slyck M.D.2; and Thomas N. James M.D., F.C.C.P.3

1 Assistant Staff Physician, Division of Cardiology
2 Associate Staff Physician, Division of Hematology
3 Professor of Medicine, Professor of Pathology, and Director of the Cardiovascular Research and Training Center, University of Alabama School of Medicine, Brimingham

A 65-year-old white man with chronic granulocytic leukemia manifested a variety of worsening atrial rhythm disturbances during his progessive clinical deterioration over a one-year period. At autopsy, leukemic infiltration involving the sinus node was evident. It is tempting to assume a cause and effect relationship from these findings. Unexplained abnormalities in cardiac rhythm in patients with leukemia should alert the clinician to the possibility of involvement of the heart by cellular infiltrate or hemorrhage. Such knowledge might help curtail the morbidity of these patients, for sometimes the arrhythmia may be amenable to local, palliative treatment.






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Copyright © 1972 by the American College of Chest Physicians.