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(Chest. 1972;61:622-628.)
© 1972 American College of Chest Physicians

Bronchiolar Carcinoma (Alveolar Cell), Another Great Imitator; A Review of 41 Cases

Louis G. Ludington M.D., F.C.C.P.1; Joseph J. Verska M.D., F.C.C.P.2; Thora Howard M.D.3; George Kypridakis M.D.4; and Lyman A. Brewer III M.D., F.C.C.P.5

1 Assistant Clinical Professor of Surgery, Loma Linda University School of Medicine, Loma Linda, California; and Thoracic Surgeon, White Memorial Medical Center
2 Assistant Clinical Professor of Surgery, Loma Linda University School of Medicine; and Chief of Thoracic Surgery, White Memorial Medical Center
3 Radiologist, White Memorial Medical Center
4 Associate Clinical Professor of Pathology, Loma Linda University School of Medicine; and Chairman, Department of Pathology, White Memorial Medical Center
5 Professor of Surgery, Loma Linda University School of Medicine; Clinical Professor of Surgery, University of Southern California School of Medicine, Los Angeles; and Thoracic Surgeon, White Memorial Medical Center

Forty-one cases of bronchiolar carcinoma in 15 years were studied for incidence, symptomatology, methods for diagnosis, treatment, and survival. This disease, once considered rare and incurable, now appears to have clear-cut characteristics and a hopeful outcome. It is unicentric in origin, slow growing, but can spread early by air embolization, lymphatics or blood stream, and can mimic any acute or chronic pulmonary disease. As early surgery offers the only cure, aggressive diagnostic work-up for suspicious pulmonary infiltrate is imperative. Half of our cases were considered inoperable at the time of admissions; these have all died. Ten showed diffuse but operable lesions and palliative resections were performed; two are living, one over four years, and a third survived two years before succumbing. Ten cases had localized disease and curative resections were attempted; seven are still living and six have reached the two-year survival mark.




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