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1 Department of Medicine and Cardiology and the Clinical Investigation Center, US Naval Hospital, San Diego
After three years of procainamide 1.0 gram daily, a 56-year-old man presented with pleurisy and pleural effusion, which progressed to pericardial effusion and tamponade, requiring two pericardiocenteses within 24 hours. After four months of prednisone therapy, he was asymptomatic.
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