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(Chest. 1972;62:62-65.)
© 1972 American College of Chest Physicians

Electrocardiographic and Ultrastructural Cardiac Effects of Phenothiazine in Rabbits

A Preliminary Report

Ramon A. Guillan M.D.1; Robert L. Smalley Ph.D.2; and Samuel Zelman M.D.3

1 Chief, Laboratory Service, Veterans Administration Hospital, Topeka, Kansas
2 Professor of Biochemistry, Department of Physical Sciences, Kansas State Teachers College, Emporia, Kansas
3 Chief, Medical Service, and Assistant Chief of Staff (GM&S), Veterans Administration Hospital, Topeka and Lecturer in Medicine, University of Kansas Medical School, Kansas City, Kansas

Electron microscopic study of the hearts of rabbits given short-term high dosages of chlorpromazine revealed changes similar to those found in phenothiazine-treated human subjects who died suddenly. These consisted of severe mitochondrial pleomorphism, loosening of myocardial fiber structure, and intracytoplasmic edema. Widening of Z-band spaces also occurred, as in the human hearts, suggesting incomplete cardiac contraction. A direct effect of phenothiazine drugs on mitochondrial structure and function is suggested and, if sufficiently widespread or strategically located, this effect can trigger changes in cardiac rhythm.






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