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(Chest. 1973;63:105-108.)
© 1973 American College of Chest Physicians

Ouabain-Induced Hypertension in a Patient with Decompensated Hypertensive Heart Disease

Raj Kumar M.D.1; Nicholas A. Yankopoulos M.D.1; and Walter H. Abelmann M.D.1

1 Thorndike Memorial Laboratory, Harvard Medical Unit, Boston City Hospital, and the Department of Medicine, Harvard Medical School, Boston

Increased systemic blood pressure after the administration of digitalis glycosides has been described both in clinical and experimental studies carried out under anesthesia. In awake and conscious man, digitalis-induced hypertension has been reported only rarely. However, hypertension occurs more often in conscious man in the presence of cardiovascular disease. To draw attention to the possibility of undesirable and even life-threatening complications, a patient is reported who developed accelerated hypertension and a stroke after the administration of ouabain. The possible mechanisms and therapy of digitalis-induced hypertension are discussed.




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 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. Manunta, B. P. Hamilton, and J. M. Hamlyn
Salt intake and depletion increase circulating levels of endogenous ouabain in normal men
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2006; 290(3): R553 - R559.
[Abstract] [Full Text] [PDF]


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