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(Chest. 1973;63:117-120.)
© 1973 American College of Chest Physicians

Acute Lupus Pneumonitis: Response to Azathioprine Therapy

Richard A. Matthay M.D.1; Leonard D. Hudson M.D.1; and Thomas L. Petty M.D., F.C.C.P.1

1 Department of Medicine, Pulmonary Disease Division, University of Colorado Medical Center, Denver

An 18-year-old girl developed an acute, fulminating lupus pneumonitis manifested by severe shortness of breath, cyanosis, fever, profound hypoxemia and diffuse pulmonary infiltrates. When the patient failed to improve significantly with prednisone, azathioprine therapy was instituted. Marked clinical, x-ray and physiologic improvement followed and the patient has remained well for 15 months. These results suggest a role for azathioprine in treating acute lupus pneumonitis not responding to steroids.






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Copyright © 1973 by the American College of Chest Physicians.