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(Chest. 1973;63:74-78.)
© 1973 American College of Chest Physicians

Acid-Base Relationships and the Cardiac Response to Aerosol Inhalation

Nancy C. Flowers M.D., F.C.C.P.1 and Leo G. Horan M.D., F.C.C.P.2

1 Chief, Section of Cardiology, Forest Hills Division, Veterans Administration Hospital; Professor of Medicine, Medical College of Georgia
2 Chief, Medical Service, Forest Hills Division, Veterans Administration Hospital; Professor of Medicine, Medical College of Georgia

In a study of 30 dogs exposed to fluoroalkane-propelled aerosol preparations it was found that half survived while the other half succumbed to a very similar pattern of rhythm disturbance which resulted in asystole. In an analysis of blood-gas data, it was found that the survivors had in common a lower pH, a higher PCOCO2 and, at certain points in the experiment, a greater base deficit. These data suggest that one factor in determining the likelihood of survival or death in young people who sniff aerosols deliberately may relate to the acid-base response of the host to the inhalant.






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Copyright © 1973 by the American College of Chest Physicians.